Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background
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- Taira Makiko
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan Tohoku University Hospital, Tohoku University, Sendai, Japan
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- Mugikura Shunji
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan Tohoku University Hospital, Tohoku University, Sendai, Japan
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- Mori Naoko
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan Tohoku University Hospital, Tohoku University, Sendai, Japan
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- Hozawa Atsushi
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
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- Saito Tomo
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan
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- Nakamura Tomohiro
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
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- Kiyomoto Hideyasu
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
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- Kobayashi Tadao
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
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- Ogishima Soichi
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan
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- Nagami Fuji
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan
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- Uruno Akira
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan
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- Shimizu Ritsuko
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan
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- Kobayashi Tomoko
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan Tohoku University Hospital, Tohoku University, Sendai, Japan
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- Yasuda Jun
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Miyagi Cancer Center, Natori, Japan
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- Kure Shigeo
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan Tohoku University Hospital, Tohoku University, Sendai, Japan Miyagi Children's Hospital, Sendai, Japan
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- Sakurai Miyuki
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
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- Motoike Ikuko N.
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Information Sciences, Tohoku University, Sendai, Japan
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- Kumada Kazuki
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
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- Nakaya Naoki
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
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- Obara Taku
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
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- Oba Kentaro
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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- Sekiguchi Atsushi
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan
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- Thyreau Benjamin
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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- Mutoh Tatsushi
- Graduate School of Medicine, Tohoku University, Sendai, Japan Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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- Takano Yuji
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan University of Human Environments, Matsuyama, Japan
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- Abe Mitsunari
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan Graduate School of Medicine, Fukushima Medical University, Fukushima, Japan
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- Maikusa Norihide
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan Graduate School of Art and Science, University of Tokyo, Tokyo, Japan
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- Tatewaki Yasuko
- Graduate School of Medicine, Tohoku University, Sendai, Japan Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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- Taki Yasuyuki
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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- Yaegashi Nobuo
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan Tohoku University Hospital, Tohoku University, Sendai, Japan Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan
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- Tomita Hiroaki
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan Tohoku University Hospital, Tohoku University, Sendai, Japan
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- Kinoshita Kengo
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan Graduate School of Information Sciences, Tohoku University, Sendai, Japan
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- Kuriyama Shinichi
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan International Research Institute of Disaster Science, Tohoku University, Sendai, Japan The United Centers for Advanced Research and Translational Medicine, Tohoku University, Sendai, Japan
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- Fuse Nobuo
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan
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- Yamamoto Masayuki
- Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Graduate School of Medicine, Tohoku University, Sendai, Japan Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan
書誌事項
- 公開日
- 2023-07-14
- 資源種別
- journal article
- DOI
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- 10.31662/jmaj.2022-0220
- 公開者
- 公益社団法人 日本医師会 / 日本医学会
この論文をさがす
説明
<p>The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of residents who experienced the Great East Japan Earthquake (GEJE) and associated tsunami. The study also aimed to promote advances in personalized healthcare and medicine related to mental health and cognitive function among the general population. We recruited participants for the first (baseline) survey starting in July 2014, enrolling individuals who were participating in either the TMM Community-Based Cohort Study (TMM CommCohort Study) or the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). We collected multiple magnetic resonance imaging (MRI) sequences, including 3D T1-weighted sequences, magnetic resonance angiography (MRA), diffusion tensor imaging (DTI), pseudo-continuous arterial spin labeling (pCASL), and three-dimensional fluid-attenuated inversion recovery (FLAIR) sequences. To assess neuropsychological status, we used both questionnaire- and interview-based rating scales. The former assessments included the Tri-axial Coping Scale, Impact of Event Scale in Japanese, Profile of Mood States, and 15-item Depression, Anxiety, and Stress Scale, whereas the latter assessments included the Mini-Mental State Examination, Japanese version. A total of 12,164 individuals were recruited for the first (baseline) survey, including those unable to complete all assessments. In parallel, we returned the MRI results to the participants and subsequently shared the MRI data through the TMM Biobank. At present, the second (first follow-up) survey of the study started in October 2019 is underway. In this study, we established a large and comprehensive database that included robust neuroimaging data as well as psychological and cognitive assessment data. In combination with genomic and omics data already contained in the TMM Biobank database, these data could provide new insights into the relationships of pathological processes with neuropsychological disorders, including age-related cognitive impairment.</p>
収録刊行物
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- JMA Journal
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JMA Journal 6 (3), 246-264, 2023-07-14
公益社団法人 日本医師会 / 日本医学会
