Impact of Residual Radioactivity Rate of <sup>99m</sup>Tc-macro Aggregated Albumin (MAA) in Syringes and Administration Routes with a Focus on Pediatric Nuclear Medicine Examinations

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  • Nakamura Yuto
    Department of Radiological Technology, Yamaguchi University Hospital
  • Kangai Yoshiharu
    Department of Radiological Technology, Yamaguchi University Hospital
  • Sato Shun
    Department of Radiological Technology, Kawasaki Medical School Hospital
  • Shibata Shigeru
    Department of Radiological Technology, Kawasaki Medical School Hospital
  • Abe Toshinori
    Department of Radiological Technology, Kawasaki Medical School Hospital
  • Mimura Hiroaki
    Department of Radiological Technology, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare
  • Inubushi Masayuki
    Department of Nuclear Medicine, Kawasaki Medical School

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  • <sup>99m</sup>Tc-macro aggregated albumin（MAA）投与時におけるシリンジと投与ルートの残留率評価—小児核医学検査を想定した低液量での検討—
  • [99m]Tc-macro aggregated albumin (MAA)投与時におけるシリンジと投与ルートの残留率評価 : 小児核医学検査を想定した低液量での検討
  • [99m]Tc-macro aggregated albumin (MAA)トウヨジ ニ オケル シリンジ ト トウヨ ルート ノ ザンリュウリツ ヒョウカ : ショウニカク イガク ケンサ オ ソウテイ シタ テイエキリョウ デ ノ ケントウ

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Abstract

<p> Purpose: The purpose of this study was to evaluate the residual radioactivity in the syringe and route of administration of a low fluid volume 99mTc-macro aggregated albumin (MAA) intended for pediatric nuclear medicine examinations. Method: We evaluated the residual characteristics, as the effect of elapsed time from drawing up of radiopharmaceuticals to plastic syringe to administration, and the effect of volume of 99mTcO4− solution to be labeled, the effect of rinsed times of plastic syringe, effect of dose of calculated by consensus guidelines for pediatric nuclear medicine and residual location in injection sets with 99mTc-MAA. Residual radioactivity was measured using planar images obtained by the gamma camera. Results: Residual radioactivity rate of 99mTc-MAA, 99mTc-MAG3, 123I-IMP showed 41.3±1.6%, 14.4±0.6%, 14.6±2.0%, respectively. 99mTc-MAA clearly showed a higher residual rate. Residual radioactivity rate increased with the extension of the elapsed time, and reached a high value of 41.3% in 30 minutes. Residual radioactivity rate was dependent on the different volume of 99mTcO4− to be labeled (4.0 ml and 8.0 ml). Residual radioactivity rate did not change when the number of rinsed was more than one. Residual rate was around 40% at all doses of calculated by consensus guidelines for pediatric nuclear medicine. Conclusion: 99mTc-MAA showed the highest residual radioactivity rate among radiopharmaceuticals used in pediatric nuclear medicine examinations. The factor that most affected the residual radioactivity rate of 99mTc-MAA was the elapsed time from draw up to the plastic syringe to administration.</p>

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