Autopsy of a patient with rapidly progressed acantholytic squamous cell carcinoma of the lower gingiva

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  • SATO Marika
    Tokyo Medical University, Department of Oral and Maxillofacial Surgery
  • HASEGAWA On
    Tokyo Medical University, Department of Oral and Maxillofacial Surgery
  • KONO Michihide
    Tokyo Medical University, Department of Oral and Maxillofacial Surgery
  • TANIGAWA Maki
    Tokyo Medical University, Department of anatomic pathology
  • ENOMOTO Ai
    Tokyo Medical University, Department of anatomic pathology
  • CHIKAZU Daichi
    Tokyo Medical University, Department of Oral and Maxillofacial Surgery

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  • 急速に進行した下顎歯肉棘融解型扁平上皮癌患者の剖検例
  • キュウソク ニ シンコウ シタ カガク シニクキョクユウカイガタ ヘンペイ ジョウヒ ガン カンジャ ノ ボウケンレイ

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<p>A 72-year-old female with a tumor in the lower gingiva was referred to our department for consultation. A clinical diagnosis of squamous cell carcinoma of the right lower gingiva (cT2N0M0) was made, and a marginal madibulectomy and elective neck dissection were performed. The histopathological diagnosis of the resected specimen was acantholytic squamous cell carcinoma (ASCC). A month after the surgery, local recurrence and bilateral cervical lymph node metastases were found. The patient underwent a mandibular segmental resection and bilateral neck dissection, and immediate reconstruction with a rectus abdominis myocutaneous free flap. Although we planned to perform chemoradiotherapy, local recurrence and multiple metastases were observed and the patient died five months after the initial diagnosis. The autopsy revealed cervical lymph node metastasis and distant metastases to the skin, lung, pleura and mesentery.</p>

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