Treatment Experience of Giant Juvenile Fibroadenomas: A Report of Two Cases

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  • Mase Junichi
    Department of Breast Surgery, Gifu Prefectural General Medical Center
  • Ogiso Atsuko
    Department of Breast Surgery, Gifu Prefectural General Medical Center
  • Nagao Yasuko
    Department of Breast Surgery, Gifu Prefectural General Medical Center

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  • 巨大若年性線維腺腫の治療経験

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Abstract

<p>Fibroadenomas, which occur predominantly in young women, sometimes grow rapidly to become huge. Such giant juvenile fibroadenomas are relatively rare. We report two cases of juvenile fibroadenoma in two young women aged 12 and 13 years old. Both patients presented with left breast swelling. Ultrasonography revealed a well-defined tumor measuring 12 cm in diameter in the first case and 9 cm in diameter in the second case. In both cases, core needle biopsy led to the diagnosis of fibroadenoma. Tumor resection was performed because of the possibility of phyllodes tumor and asymmetry in shape between the left and right breasts. Histopathology of the resected specimens in both cases confirmed the diagnosis of fibroadenoma, and there were no malignant findings. A review of the literature published over the last 33 years revealed 34 cases of fibroadenoma and 10 cases of phyllodes tumor in children under 15 years of age. Previous reports demonstrated associations among tumor growth, plasma estrogen levels, and the Ki-67 index; however, no clear association was found in this case.</p><p>In both the cases reported herein, the postoperative course was good, the cosmeticity was maintained, and there was no recurrence. Considering the low frequency of malignant and phyllodes tumors, it is important to make as much effort as possible to preserve the breast tissue.</p>

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