Dual Feedback-controlled Microrheology of Biological Samples

DOI Web Site 24 References Open Access
  • NISHIZAWA Kenji
    Department of Physics, Graduate School of Science, The University of Tokyo
  • MIZUNO Daisuke
    Department of Physics, Graduate School of Sciences, Kyushu University

Bibliographic Information

Other Title
  • 多重feedback制御されたマイクロレオロジーによる生体試料計測
Published
2023
Resource Type
journal article
DOI
  • 10.5650/oleoscience.23.491
Publisher
Japan Oil Chemists' Society

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Description

<p>Microrheology (MR) using optical trapping and laser interferometry is particularly useful for biological samples whose rheology remarkably depends on time and length scales. However, it has been challenging to measure samples like living cells that exhibit large fluctuations (flow) and can be damaged by laser light. Recently, with the feedback control of the optical-trapping force and the probe position, it has become possible to conduct precise, minimally invasive MR measurements of soft matter and living samples. In this paper, after explaining these latest techniques, we will present examples of measurements: the linear viscoelasticity within living cells, and the force-induced nonlinear fluctuations in the in vitro cytoskeleton.</p>

Journal

  • Oleoscience

    Oleoscience 23 (9), 491-498, 2023

    Japan Oil Chemists' Society

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