Behavior and heart rate variability after intranasal administration of oxytocin in Holstein steers
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- YOSHIDA Masumi
- Department of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan Chiba Prefecture Agricultural Mutual Aid Union Federation, Chiba, Japan
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- MOMITA Kosuke
- School of Agriculture, Tokai University, Kumamoto, Japan
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- KUWAHARA Masayoshi
- Department of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
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- KASUYA Etsuko
- National Agriculture and Food Research Organization, Ibaraki, Japan
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- SUTOH Madoka
- College of Agriculture, Ibaraki University, Ibaraki, Japan
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- YAYOU Ken-ichi
- National Agriculture and Food Research Organization, Ibaraki, Japan
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抄録
<p>Oxytocin (OXT) is a neuropeptide that regulates memory, emotion, stress response, and behavior in the brain. In our previous study with cattle, we demonstrated the anti-stress effect of intracerebroventricularly administered OXT on the central nervous system. However, it is important to investigate the effects of this peptide after intranasal administration, as it offers convenience and non-invasiveness for practical use. Therefore, this study investigated the effects of intranasal OXT on the behavior and autonomic nervous system of Holstein steers. The experiment followed a within-subjects design, including a total of six steers. Each steer received intranasal administration of either 1 mL of saline (SAL), 100 µg OXT (OXT100), or 200 µg OXT (OXT200). However, due to some issues, the sample size for the OXT200 group was reduced to five. After these treatments, we conducted electrocardiography recordings to analyze heart rate variability (HRV) and also made behavioral observations for 90 min. OXT200 tended to increase the time spent ruminating while lying down (Steel’s multiple comparison test; P=0.053). In contrast, OXT treatment did not affect HRV indices. In conclusion, the current OXT dosage did not significantly affects behavior or the autonomic nervous system. However, the observed tendency to increase rumination may suggest a central effect of OXT.</p>
収録刊行物
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- Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ
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Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ 85 (9), 956-963, 2023
公益社団法人 日本獣医学会