Risk Factors for Candidemia in Severe Burns

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  • Ochiai Koji
    Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
  • Kaita Yasuhiko
    Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
  • Aizawa Yota
    Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
  • Tanaka Yuya
    Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
  • Yoshikawa Kei
    Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
  • Yamaguchi Yoshihiro
    Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine

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  • 重症熱傷患者におけるカンジダ血症のリスク因子の検討

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Abstract

<p> Aim: Burn patients are a high-risk group for developing invasive candidiasis, but there are few reports on risk factors for candidemia. The purpose of this study was to clarify the risk factors for candidemia in patients with severe burns.<br> Methods: Data from 72 severe burn patients over a 14-year period from 2008 were retrospectively analyzed. Patients with severe burns were defined as those with more than 30% second-degree burns or more than 10% third-degree burns. Candidemia was defined as the isolation of Candida from blood culture samples.<br> Results: Univariate analysis showed significant differences in total burn surface area (TBSA) and mortality between the candidemia and the non-candidemia groups. Multivariate logistic analysis revealed that TBSA was independently associated with the development of candidemia. The optimal TBSA cutoff value for candidemia was 50, and a TBSA value of 50 could predict complications of candidemia with a sensitivity of 63% and a specificity of 80%.<br> Conclusion: TBSA value could be a risk factor for candidemia in severe burn patients. Patients with a TBSA of more than 50% should be considered as at risk for development of candidemia.</p>

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