COMPARISON OF THE QUALITY OF WHOLE BLOOD-DERIVED, PAS-REPLACED PLATELET CONCENTRATES DURING ROOM TEMPERATURE OR REFRIGERATED STORAGE
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- Fujihara Mitsuhiro
- Japanese Red Cross Hokkaido Block Blood Center
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- Kanashiki Takumi
- Japanese Red Cross Hokkaido Block Blood Center
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- Fuse Hisae
- Japanese Red Cross Hokkaido Block Blood Center
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- Arisawa Fuminori
- Japanese Red Cross Hokkaido Block Blood Center
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- Wakamoto Shinobu
- Japanese Red Cross Hokkaido Block Blood Center
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- Ikuta Katsuya
- Hokkaido Red Cross Blood Center
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- Akino Mitsuaki
- Japanese Red Cross Hokkaido Block Blood Center
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- Kino Shuichi
- Japanese Red Cross Hokkaido Block Blood Center
Bibliographic Information
- Other Title
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- 全血由来PAS置換血小板濃厚液の室温保存と冷蔵保存における品質の比較
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Abstract
<p>Pooled platelet concentrate (PC) that is prepared from whole blood may be a solution to the shortage of blood donors caused by the declining birthrate and aging population. Here, we prepared a pooled platelet additive solution (PAS)-PC from 400 ml whole blood by replacing a portion of the plasma with PAS using TACSI, a European-specification large-capacity centrifuge with an automatic blood separation function. We then compared quality during storage at room temperature (22°C) and refrigeration (4°C) over 21 days.</p><p>Pooling of four buffy coats (BCs) yielded more than 10 units of pooled PAS-PC (n=4), and pooling of five BCs yielded more than 15 units of pooled PAS-PC (n=4). Each pooled PAS-PC met the quality standard of PC in Japan. On room temperature storage, pooled PAS-PC maintained good platelet aggregation, % hypotonic shock response (%HSR), and clot formation capacity for up to 5 days. On refrigerated storage, %HSR decreased early after storage, but aggregation and clot formation capacity remained similar to those on day 5 of room temperature storage until day 14.</p><p>These findings suggest that pooled PAS-PC of good quality can be obtained from 400 ml whole blood using the European specification TACSI. In addition, pooled PAS-PC can be stored for up to 14 days by refrigerated storage.</p>
Journal
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- Japanese Journal of Transfusion and Cell Therapy
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Japanese Journal of Transfusion and Cell Therapy 69 (5), 589-598, 2023-10-05
The Japan Society of Transfusion Medicine and Cell Therapy
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Details 詳細情報について
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- CRID
- 1390297902461203712
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- ISSN
- 18830625
- 18813011
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed