MRIによるグリンパティックシステム機能の非侵襲的評価

DOI
  • 鎌形 康司
    順天堂大学大学院医学研究科放射線診断学講座
  • 高林 海斗
    順天堂大学大学院医学研究科放射線診断学講座

書誌事項

タイトル別名
  • Noninvasive magnetic resonance imaging measures of glymphatic system activity

抄録

<p>The glymphatic system is described as a perivascular brain network that facilitates CSF and interstitial fluid exchange. It has been reported that the activity of the glymphatic system changes dynamically with sleep, aging, alcohol intake, etc., and it is described that it is closely related to the onset of dementia. It has also been suggested that a contribution of an impaired glymphatic system to the accumulation of amyloid–beta (Aβ), which are identified as pathological hallmarks of Alzheimer disease (AD). MRI measurements, such as the diffusivity along the perivascular space (PVS) represented by the ALPS index, the PVS volume, and the fractional volume of free water (FW) in the brain parenchyma, were recently revealed as promising candidates for the evaluation of the glymphatic system function.</p>

収録刊行物

  • 神経治療学

    神経治療学 40 (4), 637-641, 2023

    日本神経治療学会

詳細情報 詳細情報について

  • CRID
    1390298278371709184
  • DOI
    10.15082/jsnt.40.4_637
  • ISSN
    21897824
    09168443
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
  • 抄録ライセンスフラグ
    使用不可

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