In vitro Azole Susceptibility Testing of Japanese Isolates of Itraconazole-Resistant Dermatophytes
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- Nojo Honoka
- Teikyo University Institute of Medical Mycology (TIMM)
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- Hiruma Junichiro
- Teikyo University Institute of Medical Mycology (TIMM) Department of Dermatology, Tokyo Medical University
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- Noguchi Hiromitsu
- Noguchi Dermatology Clinic
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- Hiruma Masataro
- Ochanomizu Institute for Medical Mycology and Allergology
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- Harada Kazutoshi
- Department of Dermatology, Tokyo Medical University
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- Makimura Koichi
- Teikyo University Institute of Medical Mycology (TIMM)
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- Kano Rui
- Teikyo University Institute of Medical Mycology (TIMM)
書誌事項
- タイトル別名
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- <i>In vitro</i> Azole Susceptibility Testing of Japanese Isolates of Itraconazole-Resistant Dermatophytes
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抄録
We conducted antifungal susceptibility testing on itraconazole (ITCZ)-resistant isolates of Trichophyton interdigitale and Trichophyton rubrum collected from Japanese patients in 2021 and 2022. The aim of the present study was to determine the most effective drug against ITCZ-resistant strains of dermatophytes. In all isolates, the minimum inhibitory concentrations (MICs) were > 32 mg/l for ITCZ, < 0.03 to 0.5 mg/l for ravuconazole (RVCZ), and < 0.03 mg/l for efinaconazole (EFCZ), luliconazole (LUCZ), and terbinafine (TRBF). Thus, in tinea unguium cases with ITCZ-resistant strains, treatment should be switched to TRBF or other azoles with a stronger antifungal efficacy, such as EFCZ, LUCZ, or RVCZ, and treatment must continue until the infectious organisms are completely eliminated.
収録刊行物
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- Medical Mycology Journal
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Medical Mycology Journal 64 (4), 103-105, 2023-10-31
日本医真菌学会
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詳細情報 詳細情報について
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- CRID
- 1390298355901181184
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- NII書誌ID
- AA12518136
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- ISSN
- 2186165X
- 18820476
- 21856486
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- NDL書誌ID
- 033162153
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- PubMed
- 38030274
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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- 抄録ライセンスフラグ
- 使用不可