Association of Serum Levels of Cholesterol Absorption and Synthesis Markers with the Presence of Cardiovascular Disease: The CACHE Study CVD Analysis

DOI 機関リポジトリ 機関リポジトリ (HANDLE) Web Site PubMed 被引用文献1件 参考文献30件 オープンアクセス
  • Katsuki Shunsuke
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
  • Matoba Tetsuya
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
  • Akiyama Yusuke
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
  • Yoshida Hiroshi
    Department of Laboratory Medicine, The Jikei University Kashiwa Hospital
  • Kotani Kazuhiko
    Division of Community and Family Medicine, Jichi Medical University
  • Fujii Hisako
    Department of Health and Medical Innovation, Osaka Metropolitan University Graduate School of Medicine
  • Harada-Shiba Mariko
    Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute
  • Ishibashi Yutaka
    Department of General Medicine, Shimane University Faculty of Medicine Jinjyukai Education & Training Center for Healthcare Professionals
  • Ishida Tatsuro
    Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine
  • Ishigaki Yasushi
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University
  • Kabata Daijiro
    Department of Medical Statistics, Osaka Metropolitan University Graduate School of Medicine
  • Kihara Yasuki
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Kurisu Satoshi
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Masuda Daisaku
    Rinku General Medical Center
  • Matsuki Kota
    Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Matsumura Takeshi
    Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University
  • Mori Kenta
    Department of General Internal Medicine, Kobe University Hospital
  • Nakagami Tomoko
    Division of Diabetology and Metabolism, Department of Internal Medicine, Tokyo Women fs Medical University School of Medicine
  • Nakazato Masamitsu
    Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
  • Taniuchi Satsuki
    Department of Medical Statistics, Osaka Metropolitan University Graduate School of Medicine
  • Ueno Hiroaki
    Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
  • Yamashita Shizuya
    Rinku General Medical Center
  • Yoshida Hisako
    Department of Medical Statistics, Osaka Metropolitan University Graduate School of Medicine
  • Tsutsui Hiroyuki
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
  • Shoji Tetsuo
    Department of Vascular Medicine, Osaka Metropolitan University Graduate School of Medicine Vascular Science Center for Translational Research, Osaka Metropolitan University Graduate School of Medicine

説明

<p> Aim: Serum levels of cholesterol absorption and synthesis markers have been associated with cardiovascular risk in the United States and European countries. In this study, we examined the relevance of these biomarkers and the presence of cardiovascular disease (CVD) in Japanese individuals. </p><p>Methods: The CACHE consortium, comprising of 13 research groups in Japan possessing data on campesterol, an absorption marker, and lathosterol, a synthesis marker measured by gas chromatography, compiled the clinical data using the REDCap system. </p><p>Results: Among the 2,944 individuals in the CACHE population, those with missing campesterol or lathosterol data were excluded. This cross-sectional study was able to analyze data from 2,895 individuals, including 339 coronary artery disease (CAD) patients, 108 cerebrovascular disease (CeVD) patients, and 88 peripheral artery disease (PAD) patients. The median age was 57 years, 43% were female, and the median low-density lipoprotein cholesterol and triglyceride levels were 118 mg/dL and 98 mg/dL, respectively. We assessed the associations of campesterol, lathosterol, and the ratio of campesterol to lathosterol (Campe/Latho ratio) with the odds of CVD using multivariable-adjusted nonlinear regression models. The prevalence of CVD, especially CAD, showed positive, inverse, and positive associations with campesterol, lathosterol, and the Campe/Latho ratio, respectively. These associations remained significant even after excluding individuals using statins and/or ezetimibe. The associations of the cholesterol biomarkers with PAD were determined weaker than those with CAD. Contrarily, no significant association was noted between cholesterol metabolism biomarkers and CeVD. </p><p>Conclusion: This study showed that both high cholesterol absorption and low cholesterol synthesis biomarker levels were associated with high odds of CVD, especially CAD.</p>

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (30)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ