Activation of Hepatic Branched-Chain α-Ketoacid Dehydrogenase Complex by Vitamin D Deficiency in Rats
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- YOSHIDA Natsuko
- Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University
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- OI Yuna
- Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University
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- KITAURA Yasuyuki
- Laboratory of Nutritional Biochemistry, Graduate School of Bioagricultural Sciences, Nagoya University
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- SHIMOMURA Yoshiharu
- Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University
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<p>Branched-chain α-ketoacid dehydrogenase (BCKDH) complex is a rate-limiting enzyme in branched-chain amino acid catabolism and is subject to inactivation via phosphorylation by BCKDH kinase (BDK). In the present study, we examined the effects of vitamin D-deficiency on hepatic BCKDH and BDK activities in rats. Rats fed a vitamin D-deficient diet long-term showed a slight but significant decrease in plasma Ca concentration, which was associated with an elevation of BCKDH activity and a decrease in BDK activity. These results suggest that vitamin D deficiency promotes BCAA catabolism via BCKDH activation, which resulted from BDK suppression. It is proposed that Ca2+-dependent BDK inhibition by thiamine pyrophosphate may be involved in the BDK suppression.</p>
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 69 (6), 490-492, 2023-12-31
一般財団法人 学会誌刊行センター
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詳細情報 詳細情報について
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- CRID
- 1390298668091192704
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 033238851
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可