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- Matsuda Tsuyoshi
- Dept. Funct. Neurosci. Inst. Biomed. Sci. Kansai Med. Univ.
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- Kobayakawa Reiko
- Dept. Funct. Neurosci. Inst. Biomed. Sci. Kansai Med. Univ.
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- Kobayakawa Ko
- Dept. Funct. Neurosci. Inst. Biomed. Sci. Kansai Med. Univ.
Bibliographic Information
- Other Title
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- グリア摂動による新たな休眠様低代謝状態誘導法の開発
Abstract
<p>Hibernation or torpor are energy-saving strategy in some thermostatic animals to survive harsh environments such as extreme cold and starvation. The ability to induce such hypometabolic states has garnered considerable interest due to its potential medical benefits. However, the mechanisms regulate these hypometabolic state remain largely unknown. Here we found that chemogenetic activation of astrocytes, a type of glial cell, could induce a torpor-like hypometabolic state in mice. In this state, body temperature and levels of oxygen consumption are kept low as in torpor. Glial activation induced hypothermia inhibited by intracerebroventricular administration of receptor X antagonist. Our findings could enable the induction of hypometabolism at any given time, and thus provide a new method for studying the mechanisms of hypometabolism. Furthermore, our results suggest the importance of glia-neural interaction in the study of hibernation and torpor.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 97 (0), 1-B-P-035-, 2023
Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390298742738683520
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed