The disturbances of menthol sensitivity in a prodromal Parkinson's disease model mice with intranasal rotenone
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- Sato Hajime
- Div. Phamacol. Meikai Univ. Sch. Dent.
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- Satoh Keitarou
- Div. Phamacol. Meikai Univ. Sch. Dent.
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- Nozaki Kazunori
- Div. Med. Info. Osaka Univ. Dent. Hosp.
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- Yugawa Misato
- Div. Orthod. Meikai Univ. Sch. Dent.
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- Kato Takafumi
- Dept. Oral Physiol. Osaka Univ. Grad. Sch. Dent.
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- Toyoda Hiroki
- Dept. Oral Physiol. Osaka Univ. Grad. Sch. Dent.
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- Katagiri Ayano
- Dept. Oral Physiol. Osaka Univ. Grad. Sch. Dent.
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- Adachi Kazunori
- Div. Phamacol. Meikai Univ. Sch. Dent.
Bibliographic Information
- Other Title
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- 遅発性パーキンソン病モデルマウスにおけるメントール感受性の変化
Abstract
<p>Parkinson’s disease (PD) causes taste impairments as well as impaired senses of smell since the early-stage. We previously reported that bitter taste impairments may occur simultaneously, but independently, with olfactory impairments in a prodromal animal model of PD. Cool/cold temperature also affects the perception of bitter taste, but it remains unclear whether bitter taste impairments in this animal model result from altered cool/cold sensitivity. We examined the changes in the menthol sensitivity, such as coolness/irritation at low/high concentrations of menthol, in 1-week intranasal rotenone-administrated mice using brief-access or 48-hour 2-bottle tests. The total number of licks during the 20 trials of 10 sec in rotenone-treated mice showed a significant increase at 2.3 mM menthol compared to the data obtained before the rotenone treatment. In 2-bottle tests, mice after rotenone treatment showed a higher aversion to menthol compared to before. Interestingly, rotenone-treated mice significantly preferred 200 μg/mL nicotine solution to that with 100 μg/mL menthol. The disturbances of the menthol sensitivity in 1-week intranasal rotenone-administrated mice may be induced by the impairment of not only transient receptor potential (TRP) ankyrin 1 channel, but also TRP melastatin 8.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 97 (0), 3-B-P-027-, 2023
Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390298742739080832
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed