Polyclonal Hyperglobulinemia with Multiple Pulmonary Cysts and Nodules: Concerning the Mechanism Underlying Cyst Formation

  • Ota Takahito
    Department of Respiratory Medicine, Yamagata Prefectual Central Hospital, Japan
  • Suzuki Hiroki
    Department of Respiratory Medicine, Yamagata Prefectual Central Hospital, Japan
  • Kawabata Yoshinori
    Division of Diagnostic Pathology, Saitama Cardiovascular and Respiratory Center, Japan
  • Hino Toshihiko
    Department of Respiratory Medicine, Yamagata Prefectual Central Hospital, Japan
  • Yanagawa Naoki
    Department of Diagnostic Pathology, Yamagata Prefectural Central Hospital, Japan

Abstract

<p>We herein report a case of polyclonal hyperglobulinemia with multiple pulmonary cysts and nodules. The histopathological findings allowed us to speculate about the mechanism underlying cyst formation in these pathological conditions, which has not yet been thoroughly elucidated. The patient was a 49-year-old woman who presented with multiple pulmonary multilocular cysts and nodules. A lung biopsy revealed features of nodular lymphoid hyperplasia. Notably, lung structure fragmentation was evident, suggesting that structural destruction may have accompanied the disease during its course. The cysts were considered to have formed due to destruction of the lung structures. </p>

Journal

  • Internal Medicine

    Internal Medicine 63 (2), 277-282, 2024-01-15

    The Japanese Society of Internal Medicine

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