Efficient and Environmentally Benign Oxidative Cleavage of Pyrrolidine-2-methanols to γ-Lactams Using 2-Iodobenzamide as a Catalyst and Oxone
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- Perumalla Hema Naga Lakshmi
- Faculty of Pharmaceutical Sciences, University of Toyama
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- Fujiwara Tomoya
- Faculty of Pharmaceutical Sciences, University of Toyama Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science
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- Okada Maki
- Faculty of Pharmaceutical Sciences, University of Toyama
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- Asakubo Kanna
- Faculty of Pharmaceutical Sciences, University of Toyama
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- Okitsu Takashi
- Faculty of Pharmaceutical Sciences, University of Toyama
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- Kasama Kengo
- Faculty of Pharmaceutical Sciences, University of Toyama
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- Nambu Hisanori
- Faculty of Pharmaceutical Sciences, University of Toyama
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- Yakura Takayuki
- Faculty of Pharmaceutical Sciences, University of Toyama
抄録
<p>The oxidative cleavage reaction of pyrrolidine-2-methanols to γ-lactams has been described. In this reaction, [4-iodo-3-(isopropylcarbamoyl)phenoxy]acetic acid and powdered Oxone (2KHSO5·KHSO4·K2SO4) were employed as the catalyst and co-oxidant, respectively. The reaction is efficient and environmentally benign because it produces various lactams from readily available substrates in moderate to excellent yields using organocatalyst and inorganic non-toxic co-oxidant.</p>
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 72 (1), 75-79, 2024-01-17
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390298831475714432
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- ISSN
- 13475223
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可