SERUM SCLEROSTIN LEVELS IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS

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Type 1 diabetes mellitus (T1DM) is associated with an increased risk of incident fractures in children, which suggests a relationship between bone health and glucose metabolism. The Wnt signaling pathway plays a role in controlling osteoblastogenesis and bone formation, and is modulated by various endogenous inhibitors, including sclerostin, a Wnt signaling pathway inhibitor. A recent study demonstrated that glucose levels directly regulate osteocyte function through sclerostin expression, suggesting a potential mechanism for the negative effects of diabetes on bone quality. Thus, this study was conducted to assess the relationship between sclerostin levels and physical, metabolic, and endocrinological factors of bone metabolism in Japanese children and adolescents with T1DM. Twenty-two patients with T1DM (14.2±4.2 ys), and 16 age-, sexand sex hormone-matched controls without diabetes mellitus (12.3±4.1 ys) were enrolled in this study. Serum sclerostin levels were significantly higher in patients with T1DM than in controls (p =0.013), without significant differences between sexes. Spearman’s rho correlation revealed a significant positive association between serum sclerostin levels and height-standard deviation score (SDS) (p=0.011), Body mass index-SDS (p=0.014), and bone- specific alkaline phosphatase (p=0.003) in all participants. These results suggest that sclerostin plays a role in T1DM-related bone fragility in Japanese children and adolescents.

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  • 秋田医学

    秋田医学 50 (2), 39-48, 2023-11-30

    秋田医学会

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