Exacerbation rates in Japanese patients with obstructive lung disease: A subanalysis of the prospective, observational NOVELTY study
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- Kawayama Tomotaka
- Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine
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- Takahashi Kenichi
- Kishiwada City Hospital
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- Ikeda Toshikazu
- Department of Pulmonary Medicine, National Hospital Organization Matsue Medical Center
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- Fukui Kenya
- AstraZeneca K.K.
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- Makita Naoyuki
- AstraZeneca K.K.
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- Tashiro Naoki
- AstraZeneca K.K.
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- Saito Junpei
- Department of Pulmonary Medicine, Fukushima Medical University, School of Medicine
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- Shirai Toshihiro
- Department of Respiratory Medicine, Shizuoka General Hospital
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- Inoue Hiromasa
- Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University
Abstract
<p>Background: Although clinical trials including asthma and COPD patients have revealed much about exacerbation frequencies, most studies are limited in that they recruited patients only with a clear diagnosis of one disease or the other, based on conventional diagnostic criteria, which may exclude many real-world patients with mixed symptoms.</p><p>Methods: NOVELTY is a global prospective observational study of patients with asthma and/or COPD from real-world practice. In this subanalysis, we compared patient characteristics of obstructive pulmonary diseases between the Japanese population (n = 820) and the overall population excluding Japanese patients (n = 10,406).</p><p>Results: The Japanese population had fewer exacerbations than the overall population across most of the physician-assessed disease severities and all diagnoses. The difference in exacerbation frequencies was more prominent in patients with COPD and asthma + COPD. The Japanese population was older, had higher former smoking rates, lower BMI, fewer respiratory symptoms, and better health-related quality of life compared with the overall population across all diagnoses.</p><p>Conclusions: We clarified differences in patient characteristics among patients with asthma and/or COPD in Japan compared with non-Japanese patients. Importantly, we found that Japanese patients with asthma and/or COPD had significantly fewer exacerbations compared with patients overall. The results from our study may contribute to the development of precision medicine and guidelines specific to Japan.</p>
Journal
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- Allergology International
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Allergology International 73 (1), 71-80, 2024
Japanese Society of Allergology
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Keywords
Details 詳細情報について
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- CRID
- 1390298930854397056
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- ISSN
- 14401592
- 13238930
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed