Association of allergic disease with Parkinson's disease: A nationally representative retrospective cohort study
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- Nam Ji Yoon
- Samsung Medical Center
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- Park Sun Jae
- Department of Biomedical Sciences, Seoul National University Hospital, Seoul National University College of Medicine
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- Song Jihun
- Department of Biomedical Sciences, Seoul National University Hospital, Seoul National University College of Medicine
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- Jeong Seogsong
- Department of Biomedical Informatics, CHA University School of Medicine
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- Choi Seulggie
- Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine
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- Park Sang Min
- Department of Biomedical Sciences, Seoul National University Hospital, Seoul National University College of Medicine Department of Family Medicine, Seoul National University Hospital, Seoul National University College of Medicine
抄録
<p>Background: The association of allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis with Parkinson's disease (PD) risk is yet unclear. In the few preceding studies, a short follow-up duration was followed for a relatively small study population, and lifestyle behaviors were not adjusted for. Therefore, there is a need for large-scale observation studies on the association of allergic disease with PD risk after considering lifestyle behaviors.</p><p>Methods: The study population consisted of 398,936 participants aged 40 years or older who underwent health screening before 1 January 2005 from the Korean National Health Insurance Service database. Starting from 1 January 2005, all participants were followed up until the date of PD event, death, or 31 December 2019. The adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for the risk of PD were calculated using multivariable Cox proportional hazards regression.</p><p>Results: Compared to non-allergic disease participants, allergic disease patients had a higher risk for PD (aHR 1.18, 95% CI 1.07-1.30) and especially, allergic rhinitis patients had a higher risk for PD (aHR 1.14, 95% CI 1.00-1.29). Allergic disease was associated with a higher risk for PD (aHR 1.24, 95% CI 1.01-1.52) among participants who were never smokers, did not consume alcohol, and exercised regularly.</p><p>Conclusions: Allergic rhinitis was associated with a higher risk for PD compared to participants without allergic rhinitis. This risk-increasing association of allergic rhinitis with PD was preserved even among people with healthy lifestyle behaviors.</p>
収録刊行物
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- Allergology International
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Allergology International 73 (1), 107-114, 2024
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390298930854480128
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可