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- 藤田 健志
- 公益財団法人相模中央化学研究所
書誌事項
- タイトル別名
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- Allylic and Vinylic Carbon-Fluorine Bond Activation via Transition Metal-Mediated and -Catalyzed Fluorine Elimination
- 公開日
- 2024-02-01
- 資源種別
- journal article
- DOI
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- 10.5059/yukigoseikyokaishi.82.130
- 公開者
- 公益社団法人 有機合成化学協会
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説明
<p>Since the carbon-fluorine (C-F) bond exhibits a high bond dissociation energy, chemical transformation involving its cleavage (C-F bond activation) has been difficult and a challenge in synthetic organic chemistry. As one solution to this problem, we established a new and efficient methodology for C-F bond activation under mild reaction conditions by taking full advantage of transition metal-mediated β- and α-fluorine elimination processes. In these studies, we investigated organometallic elementary steps such as (i) oxidative cyclization, (ii) nucleophilic addition, and (iii) electrophilic addition, as bond-forming processes that produce intermediates suitable for fluorine elimination. By combining these processes with fluorine elimination, we systematically developed various synthetic reactions via allylic and vinylic C-F bond activation of fluoroalkenes. In addition, fluorophilic boron or silicon compounds were found to serve as fluorine captors, thereby promoting catalytic reactions by regenerating active species from inert metal fluorides, which were often generated in metal-mediated fluorine elimination.</p>
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 82 (2), 130-142, 2024-02-01
公益社団法人 有機合成化学協会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390299086443098752
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- ISSN
- 18836526
- 00379980
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- Crossref
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可
