- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Automatic Translation feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Platelet aggregation-promoting activity of chitosan sheet with porous structure
-
- Kurozumi Seiji
- Koyo Chemical Co., Ltd.
-
- Yamashita Masafumi
- Medikit Co., Ltd.
-
- Soejima Keiji
- New Tac Kasei Co., Ltd.
-
- Uemura Masahiko
- New Tac Kasei Co., Ltd.
-
- Izumi Ryotaro
- Koyo Chemical Co., Ltd.
-
- Yamamoto Masaji
- Koyo Chemical Co., Ltd.
-
- Takada Kazuaki
- Medikit Co., Ltd.
Bibliographic Information
- Other Title
-
- 多孔質キトサンシートの血小板凝集促進作用
Search this article
Description
<p>In this study, we investigated the platelet aggregation-promoting effects of porous chitosan sheet. Chitosan sponge was manufactured as follows, first, chitosan was dissolved in acetic acid aqueous solution, next frozen to as sherbet ice to obtain homogeneous frozen ice, and the sherbet ice was lyophilized, and then heat-treated. Chitosan sheet (chitosan acetate) was a hemostatic material obtained by pressing the chitosan sponge and finally sterilizing by gamma rays. The chitosan sponge had homogeneous porous structure on the surface and cross section with controlled median pore diameter of 97 μm by adding less than 2% ethanol of the final concentration to chitosan acetate solution, While the chitosan sheet had smaller porous structure with the median diameter of 32 μm. Chitosan sponge and chitosan sheet were absorbed quickly, and chitosan sheet showed a decrease in eluted acetic acid and an increase in breaking strength after water absorption by heat treatment at no less than 85 ℃ for 24h. We evaluated the platelet aggregation-promoting activity of chitosan sheet by measuring platelet factor 4 (PF4) and β-thromboglobulin (β-TG) released from aggregated platelets, after contacting with human platelet rich plasma (PRP). Chitosan sheet significantly released the higher amounts of PF4 and β-TG than gauze, hemostatic bandage of chitosan containing acetic acid and chitosan fiber (p < 0.01). These results suggest that chitosan sheet function as a hemostatic material by promoting platelet aggregation.</p>
Journal
-
- Functional Food Research
-
Functional Food Research 19 (0), 100-111, 2023-10-12
Society for Functional Food Research
- Tweet
Details 詳細情報について
-
- CRID
- 1390299130048980864
-
- ISSN
- 24343048
- 24323357
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
-
- Abstract License Flag
- Disallowed