One-Year Clinical Outcomes and Prognostic Factors Following Revascularization in Patients With Acute Limb Ischemia　― Results From the RESCUE ALI Study ―

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  • Tan Michinao
    Cardiovascular Center Tokeidai Memorial Hospital
  • Takahara Mitsuyoshi
    Department of Diabetes Care Medicine, Osaka University Graduate School of Medicine
  • Haraguchi Takuya
    Department of Cardiology, Sapporo Heart Center
  • Uchida Daiki
    Department of Vascular Surgery, Asahikawa Medical University
  • Dannoura Yutaka
    Department of Cardiovascular Medicine, Sapporo City General Hospital
  • Shibata Tsuyoshi
    Department of Cardiovascular Surgery, Sapporo Medical University
  • Iwata Shuko
    Cardiovascular Center Tokeidai Memorial Hospital Department of Cardiovascular Medicine, Nayoro City General Hospital
  • Azuma Nobuyoshi
    Department of Vascular Surgery, Asahikawa Medical University

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<p>Background: Acute limb ischemia (ALI) is a limb- and life-threatening condition and urgent treatment including revascularization should be offered to patients unless the limb is irreversibly ischemic. The aim of this study was to investigate 1-year clinical outcomes and prognostic factors following revascularization in patients with ALI.</p><p>Methods and Results: A retrospective, multicenter, nonrandomized study examined 185 consecutive patients with ALI treated by surgical revascularization (SR), endovascular revascularization (ER), or hybrid revascularization (HR) in 6 Japanese medical centers from January 2015 to August 2021. The 1-year amputation-free survival (AFS) rate was estimated to be 69.2% (95% confidence interval [CI], 62.8–76.2%). There were no significant differences among SR, ER, and HR regarding both technical success and perioperative complications. Multivariate analysis revealed that Rutherford category IIb and III ischemia (hazard ratio [HR]: 1.86; 95% CI: 1.06–3.25), supra- to infrapopliteal lesion (HR: 2.06; 95% CI: 1.08–3.95), and technical failure (HR: 2.58; 95% CI: 1.49–4.46) were independent risk factors for 1-year AFS.</p><p>Conclusions: Rutherford category IIb and III ischemia, supra- to infrapopliteal lesions, and technical failures were identified as independent risk factors for 1-year AFS. Furthermore, patients with multiple risk factors had a lower AFS rate.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 88 (3), 331-338, 2024-02-22

    一般社団法人 日本循環器学会

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