Clinical features and effects of shunt surgery in patients with progressive supranuclear palsy and idiopathic normal pressure hydrocephalus
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- M.D. Yamahara Naoki
- Department of Neurology, Gifu University Graduate School of Medicine
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- M.D., Ph.D. Yoshikura Nobuaki
- Department of Neurology, Gifu University Graduate School of Medicine
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- M.D., Ph.D. Shimohata Takayoshi
- Department of Neurology, Gifu University Graduate School of Medicine
Bibliographic Information
- Other Title
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- 進行性核上性麻痺および特発性正常圧水頭症の合併例の臨床的特徴とシャント術の効果
Abstract
<p>This study aimed to retrospectively review the frequency and clinical features of 13 patients with progressive supranuclear palsy (PSP) and idiopathic normal pressure hydrocephalus (iNPH). All patients were found to have PSP-Richardson’s syndrome (PSP-RS). Shunt surgery was effective in 5 of 11 patients (45.5%). A comparison of these 5 patients who responded to shunt surgery versus the remaining 6 patients revealed a significant difference in the reduction of frontal lobe blood flow on cerebral perfusion single-photon emission computed tomography (SPECT) (P = 0.018). These results suggest that PSP-RS is common in patients with PSP and iNPH and indicate the usefulness of cerebral perfusion SPECT in estimating the effect of shunt surgery.</p>
Journal
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- Rinsho Shinkeigaku
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Rinsho Shinkeigaku 64 (2), 113-116, 2024
Societas Neurologica Japonica