Impact of Electrocardiographic Parameters on Sudden Death in Patients Receiving Maintenance Hemodialysis: Ten-Year Outcomes of the Q-Cohort Study

DOI Web Site PubMed 38 References
  • Hiyamuta Hiroto
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Yamada Shunsuke
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Nakano Toshiaki
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Taniguchi Masatomo
    Fukuoka Renal Clinic
  • Masutani Kosuke
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University
  • Tsuruya Kazuhiko
    Department of Nephrology, Nara Medical University
  • Kitazono Takanari
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

Description

<p> Aim: Sudden death is one of the most common causes of death among hemodialysis patients. Electrocardiography (ECG) is a noninvasive and inexpensive test that is regularly performed in hemodialysis clinics. However, the association between abnormal ECG findings and the risk of sudden death in hemodialysis patients is yet to be fully elucidated. Thus, the aim of this study was to determine the ECG parameters linked to sudden death in patients undergoing hemodialysis.</p><p>Methods: The Q-Cohort Study is a multicenter, longitudinal, observational study of hemodialysis patients. In this study, 1,153 Japanese hemodialysis patients aged ≥ 18 years with ECG data recorded within 1 year of study enrollment were followed up for 10 years. Cox proportional hazards models were used to estimate the multivariate-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for the association between ECG parameters and sudden death.</p><p> Results: During the median follow-up period of 9.0 years, 517 patients died, 76 of whom exhibited sudden death. After adjusting for confounding factors, higher heart rate, QT prolongation, and left ventricular hypertrophy as per the Sokolow–Lyon voltage criteria were found to be independently associated with an increased risk of sudden death. The adjusted HRs [95% CIs] for each abnormal ECG parameter were 2.02 [1.05–3.89], 2.10 [1.30–1.77], and 1.91 [1.18–3.09], respectively.</p><p>Conclusions: Higher heart rate, QT prolongation, and left ventricular hypertrophy on ECG have been determined to be associated with an increased risk of sudden death. Therefore, regular ECG recording could enable medical practitioners to identify hemodialysis patients who require intervention to prevent lethal arrhythmia.</p>

Journal

References(38)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top