A case of small cell lung cancer with pineal metastasis

DOI
  • Shimada Nagashige
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center
  • Kodaka Norio
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center
  • Nakano Chihiro
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center
  • Oshio Takeshi
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center
  • Oharazeki Toshiaki
    Department of Pathology, Toho University Ohashi Medical Center
  • Matsuse Hiroto
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center

Bibliographic Information

Other Title
  • 【投稿/症例報告】松果体転移を認めた原発性小細胞肺癌の1例

Abstract

A 51-year-old man presented at our hospital with chief complaints of headache and amnesia. Magnetic resonance imaging of the head revealed hydrocephalus caused by a pineal tumor, for which endoscopic third ventriculostomy and tumor biopsy were performed. The patient was subsequently diagnosed with a neuroendocrine tumor. The shadow of a mass was also observed in the right pulmonary hilar region, which was diagnosed as small cell lung cancer based on bronchoscopic biopsy. Since the tumor was histologically similar to the pineal tumor, chemotherapy with immune checkpoint inhibitors was performed for advanced small cell lung cancer with pineal metastasis. Pineal metastasis of small cell lung cancer is rare and no previous reports have described its treatment using chemotherapy in combination with an immune checkpoint inhibitor. We report here the course of treatment for this patient along with a review of the literature.

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