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- TAHARA Yuichi
- Department of Internal Medicine, Saiseikai Matsusaka General Hospital
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- HASHIMOTO Akira
- Department of Internal Medicine, Saiseikai Matsusaka General Hospital
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- OWA Hirono
- Department of Internal Medicine, Saiseikai Matsusaka General Hospital
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- ONO Takahiro
- Department of Internal Medicine, Saiseikai Matsusaka General Hospital
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- KURODA Naoki
- Department of Internal Medicine, Saiseikai Matsusaka General Hospital
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- AOKI Masatoshi
- Department of Internal Medicine, Saiseikai Matsusaka General Hospital
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- FUKE Hiroyuki
- Department of Internal Medicine, Saiseikai Matsusaka General Hospital
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- KAWABATA Hiroyuki
- Department of Internal Medicine, Saiseikai Matsusaka General Hospital
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- WAKITA Yoshihiro
- Department of Internal Medicine, Saiseikai Matsusaka General Hospital
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- SHIMIZU Atsuya
- Department of Internal Medicine, Saiseikai Matsusaka General Hospital
Bibliographic Information
- Other Title
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- 食道癌化学療法中に大動脈血栓症を呈した1例
Abstract
<p>A 59-year-old man presented to our hospital with a chief complaint of epigastric pain. Pertinent history included a distal gastrectomy for gastric cancer and alcohol dependence. He underwent contrast-enhanced computed tomography (CT) and esophagogastroduodenoscopy, which led to a diagnosis of esophageal cancer (cT2N2M1, stage IVb). Subsequently, he underwent chemotherapy using 5-fluorouracil and cis-diamminedichloroplatinum and radiotherapy. A total of 44 days after treatment initiation, the patient experienced nausea and hepatobiliary enzyme elevation. CT and abdominal ultrasonography were performed, and he was diagnosed with an abdominal aortic thrombus. Intravenous heparin was administered as an anticoagulant therapy. Twenty-two days after treatment initiation, the thrombus was no longer visible on abdominal ultrasonography. The patient was then treated with warfarin. It cannot be ruled out that the patient's hepatobiliary enzyme elevation was induced by the anticancer drugs. However, enzyme elevation improved with the disappearance of the abdominal aortic thrombus, suggesting that the aortic thrombus may have contributed to the hepatobiliary enzyme elevation. No thrombus recurrence was observed until the patient's death after an initial treatment with antithrombotic agents. This case indicates that malignant tumors and chemotherapy can cause aortic thrombi, and thus, care should be exercised in monitoring this potential complication.</p>
Journal
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- Nippon Shokakibyo Gakkai Zasshi
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Nippon Shokakibyo Gakkai Zasshi 121 (3), 212-220, 2024-03-10
The Japanese Society of Gastroenterology