Epithelioid hemangioendothelioma with metachromatic mucous-like material

DOI Web Site 8 References
  • NOGUCHI Hiroshi
    Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
  • TOKUMITSU Takako
    Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
  • MORITA Katsuyo
    Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
  • MINEMATSU Eiko
    Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
  • SHIRAHAMA Kosei
    Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
  • KUROKI Eiteru
    Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki
  • MAEKAWA Kazunari
    Division of Pathophysiology, Department of Pathology, Faculty of Medicine, University of Miyazaki
  • SATO Yuichiro
    Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki Department of Diagnostic Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki

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  • 異染性粘液様物質を認めた類上皮血管内皮腫の 1 例

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<p>Background : Lung epithelioid hemangioendothelioma (EHE) is a rare vascular neoplasm, and diagnosis by cytology is often challenging. We report a case of EHE diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) biopsy. We also reviewed the cytology slides and found metachromatic mucous material by May-Giemsa staining.</p><p>Case : A 50s-year-old woman underwent EBUS-TBNA of a left hilar mass. Cytologic examination showed loosely cohesive clusters of epithelioid cells containing irregular nuclei with nucleoli and intracytoplasmic vacuoles. These cytologic findings suggested adenocarcinoma, however, histopathology revealed positive results for endothelial markers, and the final pathological diagnosis was EHE. We reevaluated the cytological findings and found metachromatic myxoid material by May-Giemsa staining of the sections.</p><p>Conclusion : The cytological features of this case were similar to those of adenocarcinoma, making differentiation between the two difficult. Detection of metachromatic interstitial mucus is useful for the diagnosis of EHE.</p>

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