Immune Checkpoint Inhibitor-induced Pancreatitis with Pancreatic Enlargement Mimicking Autoimmune Pancreatitis: A Case Report and Review of the Literature
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- Tanabe Kiyokuni
- Department of Medicine, Division of Gastroenterology, Jichi Medical University, Japan
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- Yokoyama Kensuke
- Department of Medicine, Division of Gastroenterology, Jichi Medical University, Japan
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- Kanno Atsushi
- Department of Medicine, Division of Gastroenterology, Jichi Medical University, Japan
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- Ikeda Eriko
- Department of Medicine, Division of Gastroenterology, Jichi Medical University, Japan
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- Ando Kozue
- Department of Medicine, Division of Gastroenterology, Jichi Medical University, Japan
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- Nagai Hiroki
- Department of Medicine, Division of Gastroenterology, Jichi Medical University, Japan
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- Koyanagi Takahiro
- Department of Obstetrics & Gynecology, Jichi Medical University, Japan
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- Sakaguchi Mio
- Department of Diagnostic Pathology, Jichi Medical University, Japan
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- Nakaya Takeo
- Department of Diagnostic Pathology, Jichi Medical University, Japan
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- Tamada Kiichi
- Department of Medicine, Division of Gastroenterology, Jichi Medical University, Japan
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- Niki Toshiro
- Department of Diagnostic Pathology, Jichi Medical University, Japan
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- Fukushima Noriyoshi
- Department of Diagnostic Pathology, Jichi Medical University, Japan
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- Lefor Alan Kawarai
- Department of Surgery, Jichi Medical University, Japan
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- Yamamoto Hironori
- Department of Medicine, Division of Gastroenterology, Jichi Medical University, Japan
抄録
<p>A 61-year-old woman was administered 35 cycles of pembrolizumab for the treatment of recurrent endometrial cancer, achieving a complete response. She presented with asymptomatic pancreatic enlargement and elevated hepatobiliary enzymes, but amylase and lipase levels were within the normal ranges. Intrapancreatic bile duct stenosis due to pancreatic enlargement was present, mimicking autoimmune pancreatitis on computed tomography performed before the onset of clinical manifestations. A histological examination of a biopsy specimen showed lymphocyte and plasma cell infiltration with dense fibrosis in the stroma. The patient was successfully treated with oral prednisolone. There were no manifestations of recurrent pancreatitis after tapering the prednisolone dose. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 63 (6), 791-798, 2024-03-15
一般社団法人 日本内科学会