Recurrent Stroke with Rapid Development of Intracranial Artery Stenosis and Subsequent Successful Mechanical Thrombectomy in Essential Thrombocythemia

  • Kato Yuji
    Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Japan
  • Iijima Shohei
    Department of Endovascular Neurosurgery, Saitama Medical University International Medical Center, Japan
  • Kohyama Shinya
    Department of Endovascular Neurosurgery, Saitama Medical University International Medical Center, Japan
  • Maeda Tomoya
    Department of Hemato-Oncology, Saitama Medical University International Medical Center, Japan
  • Sato Tsugumi
    Department of Pathology, Saitama Medical University International Medical Center, Japan
  • Takahashi Shinichi
    Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Japan
  • Suda Satoshi
    Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Japan

抄録

<p>Essential thrombocythemia is a myeloproliferative neoplasm. Ischemic stroke is frequently the first manifestation of essential thrombocythemia. We herein report a patient with JAK2V617 mutation-positive essential thrombocythemia who developed recurrent ischemic stroke with rapid development of intracranial artery stenosis and subsequently underwent successful mechanical thrombectomy. The high JAK2V617F allele burden in our patient (58.4%) may have affected the patient's condition. We discuss similar reports in the literature and the possible pathophysiologic mechanism of large artery involvement in these patients. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 63 (6), 847-852, 2024-03-15

    一般社団法人 日本内科学会

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