Diversity and Inclusion in the Treatments of Pediatric Brain Tumors

  • Kondo Akihide
    Department of Neurosurgery, Juntendo University Faculty of Medicine

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Other Title
  • 小児脳腫瘍の多様性と多角的治療戦略
  • ―Diversity and Inclusionの観点から―

Abstract

<p>  Diversity and inclusion are required to improve the efficiency of social activities. The clinical field is no exception. The involvement of people from various social backgrounds and the convergence and resonance of different views and ideas make it possible to address complex medical issues. This paper examined the prospects of treating pediatric brain tumors based on this concept.</p><p>  First, pediatric brain tumors are a very diverse group of diseases. The age of onset also varies widely. In other words, since children are growing and developing, the physical, psychological, and environmental factors differ greatly depending on the child's age. Therefore, the tumors that develop are also very different from those in adults. Furthermore, the classification of pediatric brain tumors and the definitions of tumor types are changing dramatically. The molecular biological characteristics of pediatric brain tumors are more reflective of the clinical presentations than the classifications based on histopathological similarities. Therefore, advances in molecular physical analysis techniques have inevitably led to new classifications of tumor types.</p><p>  Under a newly proposed classification, medulloblastomas is divided into at least four clinically and molecularly distinct groups, which have been further subdivided into 12 subtypes. Ependymal tumors are classified into nine subsets. What was once a single tumor type has been subdivided into multiple subtypes.</p><p>  However, no appropriate treatment has been proposed for each tumor subtype. Consequently, new classifications do not necessarily lead to an improved prognosis. In the future, it is necessary to find a treatment for each of these tumor types through the collaborative efforts of individuals with various knowledge and expertise in this field. To this end, promoting follow-ups and social acceptance after the cure of pediatric brain tumors is essential. It is expected that the treatment and prognosis of pediatric brain tumors will improve as society becomes more inclusive.</p>

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