Clinical Significance of the Triglyceride-Glucose Index in Patients Requiring Nonsurgical Intensive Care
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- Nishigoori Suguru
- Division of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital
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- Shirakabe Akihiro
- Division of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital
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- Okazaki Hirotake
- Division of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital
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- Matsushita Masato
- Division of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital
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- Shibata Yusaku
- Division of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital
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- Shigihara Shota
- Division of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital
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- Sawatani Tomofumi
- Division of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital
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- Tani Kenichi
- Division of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital
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- Kiuchi Kazutaka
- Division of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital
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- Kobayashi Nobuaki
- Division of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital
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- Asai Kuniya
- Department of Cardiovascular Medicine, Nippon Medical School
抄録
<p>The evaluation of triglyceride-glucose (TyG) index has not been sufficient in patients requiring nonsurgical intensive care.</p><p>A total of 3,906 patients who required intensive care were enrolled. We computed the TyG index using the value on admission by the following formula: ln [triglyceride (mg/dL) × glucose (mg/dL) /2]. Patients were divided into three groups according to the TyG index quartiles: low (quartile 1 [Q1]; TyG index ≤ 8.493, n = 977), middle (Q2/Q3; 8.494 ≤ TyG index ≤ 9.536, n = 1,953), and high (Q4; TyG index > 9.537, n = 976). The median (interquartile range) TyG index was 9.00 (8.50-9.54); acute coronary syndrome (ACS) had the highest TyG index among all etiologies at 9.12 (8.60-9.68). A multivariate logistic regression model showed that ACS (odds ratio [OR], 2.133; 95% confidence interval [CI], 1.783-2.552) were independently correlated with high TyG index. A Cox proportional hazards regression model revealed that, in ACS, the Q2/Q3 and Q4 groups were independent predictors of 30-day all-cause mortality (hazard ratio [HR], 1.778; 95% CI, 1.014-3.118; HR, 2.986; 95% CI, 1.680-5.308; respectively) and that in acute heart failure [AHF], the Q4 group was a converse independent predictor of 30-day all-cause mortality (HR, 0.488; 95% CI, 0.241-0.988).</p><p>High TyG index was linked to ACS and negative outcomes in the ACS group; in contrast, low TyG index was associated with adverse outcomes in the AHF group.</p>
収録刊行物
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- International Heart Journal
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International Heart Journal 65 (2), 180-189, 2024-03-30
一般社団法人 インターナショナル・ハート・ジャーナル刊行会