Development of a “Medication Questionnaire” to Prevent Polypharmacy: Multicenter Joint Research
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- Watanabe Tomoki
- Department of Pharmacy, National Center of Neurology and Psychiatry
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- Mizokami Fumihiro
- Department of Pharmacy, National Center for Geriatrics and Gerontology Department of Education and Innovation Training for Pharmacy, National Center for Geriatrics and Gerontology
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- Ishikawa Shiori
- Department of Pharmacy, National Hospital Organization Yokohama Medical Center
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- Takuma Rie
- Department of Pharmacy, National Center for Child Health and Development
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- Ikoma Kaori
- Department of Pharmacy, National Cerebral and Cardiovascular Center
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- Watabe Daisuke
- Department of Pharmacy, National Cancer Center Hospital
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- Shirai Tsuyoshi
- Department of Pharmacy, National Hospital Organization Disaster Medical Center
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- Seto Keisuke
- Department of Pharmacy, National Center for Global Health and Medicine
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- Ishii Mariko
- Department of Pharmacy, National Center for Child Health and Development
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- Mase Hiroki
- Department of Pharmacy, National Hospital Organization Sakakibara National Hospital
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- Shimazu Taichi
- Division of Behavioral Sciences,<sup> </sup>Institute for Cancer Control, National Cancer Center
Bibliographic Information
- Other Title
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- ポリファーマシー対策のための「おくすり問診票」の開発:多施設共同研究
Abstract
<p>Background: Polypharmacy increases the risk of adverse drug reactions due to the combinatorial effects of multiple drugs. This problem is associated with an aging population and increasing demand for drug therapies. We aimed to develop a “medication questionnaire” to prevent polypharmacy.</p><p>Methods: We created a “prototype medication questionnaire” after collecting insights from six national centers in Japan. We disseminated this questionnaire to pharmacists from September 1 to November 30, 2021, to collect information on drugs used by inpatients. We compiled the responses to create a broadly applicable “medication questionnaire.”</p><p>Results: Of 1,467 patients aged 50.7 ± 27.6 years taking 7.3 ± 4.8 medications, 43.8% (643/1,467) were using 1.6 ± 1.6 potentially inappropriate medications (PIMs). Geriatric syndrome and adverse drug events were present in 67.0% (588/878) of patients and included lightheadedness/falls (29.6%, 260/878) and anorexia (27.1%, 238/878). Adverse effects were higher among older adults (76.0%, 447/588, p < 0.01). We improved the “medication questionnaire” by changing the self-answer format; it is now available for open access (https://www.ncgg.go.jp/hospital/news/20230829-1.html).</p><p>Conclusions: We confirmed the possibility of readily identifying polypharmacy-associated problems, including geriatric syndrome and adverse drug events, and developed a “medication questionnaire” to prevent polypharmacy. When used in conjunction with the publicly available list of PIMs, we can identify drugs that should be considered for dose reduction and facilitate the optimization of prescribed regimens. We intend to use the results of this study as a reference to resolve polypharmacy-related issues and perform safe and appropriate pharmaceutical interventions.</p>
Journal
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- Journal of Geriatric Pharmacy
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Journal of Geriatric Pharmacy 7 (1), 16-24, 2024-03-31
Japanese Society of Geriatric Pharmacy
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Details 詳細情報について
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- CRID
- 1390299837599460608
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- ISSN
- 24334065
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed