So You Want to Image Myelin Using MRI: Magnetic Susceptibility Source Separation for Myelin Imaging
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- Lee Jongho
- Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
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- Ji Sooyeon
- Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
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- Oh Se-Hong
- Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea
抄録
<p>In MRI, researchers have long endeavored to effectively visualize myelin distribution in the brain, a pursuit with significant implications for both scientific research and clinical applications. Over time, various methods such as myelin water imaging, magnetization transfer imaging, and relaxometric imaging have been developed, each carrying distinct advantages and limitations. Recently, an innovative technique named as magnetic susceptibility source separation has emerged, introducing a novel surrogate biomarker for myelin in the form of a diamagnetic susceptibility map. This paper comprehensively reviews this cutting-edge method, providing the fundamental concepts of magnetic susceptibility, susceptibility imaging, and the validation of the diamagnetic susceptibility map as a myelin biomarker that indirectly measures myelin content. Additionally, the paper explores essential aspects of data acquisition and processing, offering practical insights for readers. A comparison with established myelin imaging methods is also presented, and both current and prospective clinical and scientific applications are discussed to provide a holistic understanding of the technique. This work aims to serve as a foundational resource for newcomers entering this dynamic and rapidly expanding field.</p>
収録刊行物
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- Magnetic Resonance in Medical Sciences
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Magnetic Resonance in Medical Sciences advpub (0), 2024
日本磁気共鳴医学会