Summary of 30 Cases of Introduction of Hydroxychloroquine for Lupus Erythematosus at the Department of Dermatology, Asahikawa Medical University

DOI

Bibliographic Information

Other Title
  • 旭川医科大学皮膚科でエリテマトーデスに対してヒドロキシクロロキンを導入した30症例のまとめ

Abstract

<p>The efficacy and safety of hydroxychloroquine (HCQ) were evaluated in 30 patients (CLE 18 cases, SLE 18 cases) with cutaneous lupus erythematosus and systemic lupus erythematosus who were introduced to it at our department. Their ages ranged from 19 to 80 years (median age 48). Four cases were male, 26 cases were female. In terms of efficacy, the Cutaneous Lupus erythematosus disease Area and Severity Index activity score (CLASI) and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) were significantly reduced; 60% of patients receiving concomitant prednisolone were able to reduce their prednisolone dose after HCQ induction. In terms of safety, due to adverse events, HCQ was discontinued in 9 patients, of whom 4 were diagnosed with drug eruptions and only 1 was able to resume the drug. Although three patients received more than 6.5 mg/kg/day of HCQ per actual body weight, none of them developed retinopathy.</p>

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Keywords

Details 詳細情報について

  • CRID
    1390299903955989888
  • DOI
    10.14924/dermatol.134.733
  • ISSN
    13468146
    0021499X
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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