Impact of Changes in Rectus Femoris Cross-Sectional Area Measured by Ultrasound on the Prognosis of Patients With Acute Heart Failure

  • Matsuo Koji
    Department of Rehabilitation, Sagamihara Kyodo Hospital
  • Yoneki Kei
    Department of Rehabilitation, Sagamihara Kyodo Hospital Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University
  • Kobayashi Kikka
    Department of Rehabilitation, Sagamihara Kyodo Hospital
  • Onoda Daiki
    Department of Rehabilitation, Sagamihara Kyodo Hospital
  • Mibu Kazuhiro
    Department of Rehabilitation, Sagamihara Kyodo Hospital
  • Furuzono Kento
    Department of Rehabilitation, Sagamihara Kyodo Hospital
  • Mashimo Noa
    Department of Rehabilitation, Sagamihara Kyodo Hospital
  • Yasuda Shiori
    Department of Rehabilitation, Sagamihara Kyodo Hospital
  • Suzuki Toru
    Department of Rehabilitation, Sagamihara Kyodo Hospital
  • Nakao Ken
    Department of Rehabilitation, Sagamihara Kyodo Hospital
  • Tatsuki Hiroaki
    Department of Rehabilitation, Sagamihara Kyodo Hospital
  • Tamiya Seiji
    Department of Cardiovascular Medicine, Sagamihara Kyodo Hospital

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<p>Background: Low muscle mass in patients with acute heart failure (AHF) is associated with poor prognosis; however, this is based on a single baseline measurement, with little information on changes in muscle mass during hospitalization and their clinical implications. This study investigated the relationship between changes in rectus femoris cross-sectional area (RFCSA) on ultrasound and the prognosis of patients with AHF.</p><p>Methods and Results: This is a retrospective evaluation of 284 AHF patients (mean [±SD] age 79.1±11.9 years; 116 female). RFCSA assessments at admission (pre-RFCSA), ∆RFCSA (i.e., the percentage change in RFCSA from admission to 2 weeks), and composite prognosis (all-cause death and heart failure-related readmission) within 1 year were determined. Patients were divided into 4 groups according to their median pre-RFCSA and ∆RFCSA after sex stratification: Group A, higher pre-RFCSA/better ∆RFCSA; Group B, higher pre-RFCSA/worse ∆RFCSA; Group C, lower pre-RFCSA/better ∆RFCSA; Group D, lower pre-RFCSA/worse ∆RFCSA. In the Cox regression analysis, with Group A as the reference, the cumulative event rate of Group C (hazard ratio [HR] 3.39; 95% confidence interval [CI] 0.71–16.09; P=0.124) did not differ significantly; however, the cumulative event rates of Group B (HR 7.93; 95% CI 1.99–31.60; P=0.003) and Group D (HR 9.24; 95% CI 2.57–33.26; P<0.001) were significantly higher.</p><p>Conclusions: ∆RFCSA during hospitalization is useful for risk assessment of prognosis in patients with AHF.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 88 (5), 713-721, 2024-04-25

    一般社団法人 日本循環器学会

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