A Case of Ulcerative Colitis That Worsened Due to Coronavirus Disease 2019 and Was Treated with Subtotal Colectomy

DOI Web Site 21 References
  • Nagayasu Ken
    Department of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine
  • Fujiyoshi Sunao
    Department of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine
  • Honma Shigenori
    Department of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine
  • Ichikawa Nobuki
    Department of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine
  • Yoshida Tadashi
    Department of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine
  • Shibata Kengo
    Department of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine
  • Matsui Hiroki
    Department of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine
  • Katsurada Takehiko
    Department of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine
  • Nakakubo Sho
    Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University
  • Hatanaka Kanako
    Hokkaido University Hospital Institute of Health Science Innovation for Medical Care, Center for Development of Advanced Diagnostics (C-DAD), biological sample management room (Biobank)
  • Taketomi Akinobu
    Department of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine

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Other Title
  • 新型コロナウイルス感染を契機に増悪し大腸亜全摘を施行した潰瘍性大腸炎の1例

Abstract

<p>Four years have passed since the first outbreak of the Coronavirus Disease 2019 (COVID-19) pandemic, but no consensus has been reached regarding its relationship with ulcerative colitis (UC). We experienced a case of UC that worsened after the patient contracted COVID-19 and required emergency surgery. The patient was a 62-year-old man who was undergoing drug treatment for UC. Symptoms such as bloody stool and abdominal pain worsened after onset of COVID-19. The dose of immunosuppressants was increased, but there was no improvement in symptoms and renal function worsened. It was determined that drug treatment had reached its limit, and 29 days after onset of symptoms, laparoscopic subtotal colectomy and ileostomy were performed. Pathological findings of the resected specimen revealed acute inflammation due to UC. Various mechanisms of organ damage caused by COVID-19 have been proposed, including direct damage by the virus and indirect damage mediated by an immune response. In such cases, early surgery should be considered when drug treatment becomes difficult.</p>

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