Improvement of tissue fibrosis in TAFRO syndrome by prednisolone monotherapy
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- KASHIWAGI Takao
- Department of Hematology, Nishiwaki Municipal Hospital
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- KASHIWAGI Yuki
- Department of Internal Medicine, Nishiwaki Municipal Hospital
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- SUZUKI Tomohide
- Department of Hematology, Nishiwaki Municipal Hospital
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- SHINGU Manami
- Department of Internal Medicine, Nishiwaki Municipal Hospital
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- KASHIWAGI Sayaka
- Department of Internal Medicine, Nishiwaki Municipal Hospital
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- HIRATA Tamaki
- Department of Internal Medicine, Nishiwaki Municipal Hospital
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- HORI Junko
- Department of Internal Medicine, Nishiwaki Municipal Hospital
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- MIYATA Keikichi
- Department of Internal Medicine, Nishiwaki Municipal Hospital
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- TAKECHI Miho
- Department of Internal Medicine, Nishiwaki Municipal Hospital
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- KISHI Minoru
- Department of Internal Medicine, Nishiwaki Municipal Hospital
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- OHNISHI Takamasa
- Department of Diagnostic Pathology, Nishiwaki Municipal Hospital
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- KATAYAMA Yoshio
- Hematology, Kobe University Graduate School of Medicine
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- IWAI Masahide
- Department of Internal Medicine, Nishiwaki Municipal Hospital
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- MATSUI Toshimitsu
- Department of Hematology, Nishiwaki Municipal Hospital
Bibliographic Information
- Other Title
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- Prednisolone単独治療により組織線維化の改善を認めたTAFRO症候群
Abstract
<p>We report the case of a 48-year-old man who presented with fatigue and weight loss. A local physician observed elevated alkaline phosphatase levels, anemia, thrombocytopenia, and renal dysfunction. Fever also appeared, and the patient was admitted to our hospital. Computed tomography revealed hepatosplenomegaly, pleural and ascitic fluid, and left axillary lymphadenopathy. Bone marrow biopsy indicated hyperplasia with increased megakaryocytes and reticulin fibrosis. Axillary lymph node biopsy showed Castleman’s disease-like features. Liver biopsy revealed proliferation of reticulin fibrosis. Therefore, TAFRO syndrome was diagnosed and treatment with 1 mg/kg prednisolone was started. Anemia and thrombocytopenia improved, and after 24 weeks of treatment, serum hyaluronic acid and type IV collagen decreased to the normal range. Bone marrow biopsy after 18 weeks of treatment showed decreased reticular fibers. In TAFRO syndrome, improvement of liver and bone marrow fibrosis can be expected with adequate intervention, and serum hyaluronic acid and type IV collagen are useful for evaluating fibrosis.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 65 (4), 237-242, 2024
The Japanese Society of Hematology
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Details 詳細情報について
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- CRID
- 1390299981562092160
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- ISSN
- 18820824
- 04851439
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed