Improvement of tissue fibrosis in TAFRO syndrome by prednisolone monotherapy

DOI

Bibliographic Information

Other Title
  • Prednisolone単独治療により組織線維化の改善を認めたTAFRO症候群

Abstract

<p>We report the case of a 48-year-old man who presented with fatigue and weight loss. A local physician observed elevated alkaline phosphatase levels, anemia, thrombocytopenia, and renal dysfunction. Fever also appeared, and the patient was admitted to our hospital. Computed tomography revealed hepatosplenomegaly, pleural and ascitic fluid, and left axillary lymphadenopathy. Bone marrow biopsy indicated hyperplasia with increased megakaryocytes and reticulin fibrosis. Axillary lymph node biopsy showed Castleman’s disease-like features. Liver biopsy revealed proliferation of reticulin fibrosis. Therefore, TAFRO syndrome was diagnosed and treatment with 1 mg/kg prednisolone was started. Anemia and thrombocytopenia improved, and after 24 weeks of treatment, serum hyaluronic acid and type IV collagen decreased to the normal range. Bone marrow biopsy after 18 weeks of treatment showed decreased reticular fibers. In TAFRO syndrome, improvement of liver and bone marrow fibrosis can be expected with adequate intervention, and serum hyaluronic acid and type IV collagen are useful for evaluating fibrosis.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 65 (4), 237-242, 2024

    The Japanese Society of Hematology

Details 詳細情報について

  • CRID
    1390299981562092160
  • DOI
    10.11406/rinketsu.65.237
  • ISSN
    18820824
    04851439
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

Report a problem

Back to top