Slowly Progressive ANCA-associated Glomerulonephritis with Strong Mesangial MPO Deposits Following a Diagnosis of Interstitial Lung Disease
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- Anzai Hitoshi
- Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Suzuki Yuki
- Division of Respiratory Medicine and Allergology, Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Ueno Masaki
- Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Asakawa Shinichiro
- Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Nagura Michito
- Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Arai Shigeyuki
- Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Yamazaki Osamu
- Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Tamura Yoshifuru
- Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Ohashi Ryuji
- Department of Integrated Diagnostic Pathology, Nippon Medical School, Japan
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- Shibata Shigeru
- Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Fujigaki Yoshihide
- Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Japan
抄録
<p>An elderly woman showed positive conversion of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCAs) following the diagnosis of interstitial lung disease (ILD) and glomerular hematuria and subsequently experienced slowly progressive glomerulonephritis. A kidney biopsy revealed chronic damage and necrotizing crescentic glomerulonephritis with mesangial MPO deposits. After corticosteroid treatment, the patient's urinalysis results and MPO-ANCA titers almost normalized and her renal function stabilized. This case is similar to recently reported cases of slowly progressive ANCA-associated glomerulonephritis. ILD likely triggered the production of MPO-ANCAs, and the accumulation of MPO deposits in the glomeruli may have contributed to the progression of her renal disease. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 63 (9), 1253-1260, 2024-05-01
一般社団法人 日本内科学会