Lambert-Eaton Myasthenic Syndrome Complicated by Anti-GABA<sub>B</sub> Receptor Encephalitis
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- Yamada Kazuki
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Yaguchi Hiroaki
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Ishikawa Kaede
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Tanaka Daiki
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Oshima Yuki
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Mizushima Keiichi
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Uwatoko Hisashi
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Shirai Shinichi
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Takahashi-Iwata Ikuko
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Matsushima Masaaki
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Tanaka Keiko
- Department of Animal Model Development, Brain Research Institute, Niigata University, Japan
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- Yabe Ichiro
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
抄録
<p>A 74-year-old man experienced diplopia, generalized muscle weakness, and acute respiratory failure. He was diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) and treated with immunotherapy, but no improvement was observed, and additional symptoms, including central apnea and hallucinations, appeared. Subsequent serum and cerebrospinal fluid (CSF) analyses confirmed the presence of GABAB receptor antibodies, indicating the coexistence of autoimmune encephalitis. Although there were no findings of malignancy, it is highly likely that occult small-cell lung carcinoma was present. When atypical symptoms occur in patients with LEMS, it is important to consider the possibility of concomitant autoimmune encephalitis. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 63 (9), 1295-1300, 2024-05-01
一般社団法人 日本内科学会