Profile of Nagasaki Islands Study (NaIS): A Population-based Prospective Cohort Study on Multi-disease

  • Miyata Jun
    Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
  • Yamanashi Hirotomo
    Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences
  • Kawashiri Shin-Ya
    Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
  • Soutome Sakiko
    Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences
  • Arima Kazuhiko
    Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences
  • Tamai Mami
    Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences Center for Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Nonaka Fumiaki
    Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
  • Honda Yukiko
    Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences Center for Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Kitamura Masayasu
    Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences
  • Yoshida Koji
    Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Shimizu Yuji
    Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences Department of Public Health, Osaka Institute of Public Health
  • Hayashida Naomi
    Division of Strategic Collaborative Research, Atomic Bomb Disease Institute, Nagasaki University
  • Kawakami Shigeru
    Department of Pharmaceutical Informatics, Nagasaki University Graduate School of Biomedical Sciences
  • Takamura Noboru
    Department of Global Health, Medicine and Welfare, Atomic Bomb Disease Institute, Nagasaki University
  • Sawase Takashi
    Department of Applied Prosthodontics, Nagasaki University Graduate School of Biomedical Sciences
  • Yoshimura Atsutoshi
    Department of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences
  • Nagata Yasuhiro
    Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
  • Ohnishi Mayumi
    Department of Public Health Nursing, Nagasaki University Graduate School of Biomedical Sciences
  • Aoyagi Kiyoshi
    Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences
  • Kawakami Atsushi
    Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences
  • Saito Toshiyuki
    Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences
  • Maeda Takahiro
    Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences Leading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences

抄録

<p>In an aging society, it is important to visualize the conditions of people living with diseases or disabilities, such as frailty and sarcopenia, and determine the environmental and genetic factors underlying such conditions. Atherosclerosis and arterial stiffness are key conditions between these factors and noncommunicable diseases. In 2014, we launched a population-based prospective open-cohort study, the Nagasaki Islands Study (NaIS), which was conducted in Goto City, located in the remote islands of Nagasaki Prefecture, Japan, mostly involving middle-aged and older residents. We conducted our own health checkups along with the annual standardized checkups organized by the municipality; recruited study participants; and started to follow them for vital status (death), migration, and occurrence of diseases, such as myocardial infarction, stroke, fracture, and human T-cell leukemia virus type 1 (HTLV-1)-associated uveitis. Our checkups were conducted as baseline surveys in different areas of Goto City during the fiscal years 2014–2016, secondary surveys during 2017–2019, and tertiary surveys since 2021, consisting of medical interviews, physical examinations, blood and urine tests, body composition measurements, osteoporosis screening, arterial stiffness measurements, carotid ultrasonography, and dental examination. A total of 4,957 residents participated in either the baseline or secondary surveys and were followed; 3,594 and 3,364 residents (aged 27–96 and 28–98 years) participated in the baseline and secondary surveys, respectively. In conclusion, the NaIS has been undertaken to reveal the influence of aging and risk factors of noncommunicable diseases and disabilities, with an aim to contribute towards better healthcare in the future.</p>

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