A Case of the Cribriform-morular Variant of Papillary Thyroid Carcinoma That Showed Progression to Poorly Differentiated Carcinoma

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  • 低分化癌への進展を伴う篩型甲状腺乳頭癌例

Abstract

<p>The cribriform-morular variant is a rare type of thyroid papillary carcinoma that primarily affects young women under the age of 30 years. This type of cancer accounts for less than 0.5% of all cases of thyroid papillary carcinoma. It could show sporadic or familial occurrence, and familial cases often exhibit APC gene mutations and are linked to familial polyposis coli.</p><p>A 27-year-old female patient was referred to our hospital with a mass lesion on her left neck. Ultrasound examination revealed a tumor measuring 35 mm in diameter in the left lobe of the thyroid gland, and the results of an aspiration needle biopsy suggested the possibility of papillary thyroid carcinoma. CT and MRI showed compression of the trachea and invasion of the esophagus by the thyroid tumor. The patient was diagnosed as having papillary thyroid cancer (cT4aN0M0, stage I) and treated by total thyroidectomy and neck dissection (D2b). Colonoscopy excluded associated with polyposis coli. Histopathological examination of the resected tumor revealed the cribriform-morular variant of papillary thyroid carcinoma with the risk of progression to poorly differentiated carcinoma (pT3N0M0, stage I). The postoperative course of the patient was uneventful, and no recurrence has been seen until date, 18 months after the surgery.</p>

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