Basis of Potent Neutralizing Activity Revealed by Structural Analysis of SARS-CoV-2 Spike Proteins in Complex with Neutralizing Antibodies

DOI Web Site 14 References Open Access
  • HIGASHIURA Akifumi
    Department of Virology，Graduate School of Biomedical and Health Sciences，Hiroshima University
  • YAMAMOTO Akima
    Department of Virology，Graduate School of Biomedical and Health Sciences，Hiroshima University
  • SAKAGUCHI Takemasa
    Department of Virology，Graduate School of Biomedical and Health Sciences，Hiroshima University
  • YASUDA Tomoharu
    Department of Immunology，Graduate School of Biomedical and Health Sciences，Hiroshima University

Bibliographic Information

Other Title
  • SARS-CoV-2スパイクタンパク質と各種中和抗体の複合体構造解析より明らかとなった中和活性の構造学的基盤

Description

<p>Here, we analyzed broadly neutralizing antibodies isolated from long-term hospitalized convalescent patients of early SARS-CoV-2 strains. Antibodies named NCV2SG48 and NCV2SG53 are highly potent to broad SARS-CoV-2 variants. To reveal the mode of action, we determined the crystal structure of the Fab fragment of NCV2SG48 or NCV2SG53 in a complex with RBD of the S proteins from the Wuhan-Hu-1 and Omicron BA.1.</p>

Journal

  • Nihon Kessho Gakkaishi

    Nihon Kessho Gakkaishi 66 (2), 115-120, 2024-05-31

    The Crystallographic Society of Japan

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