Effect of Ondansetron on Postoperative Nausea and Vomiting and Food Intake after Knee Arthroplasty

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  • MURAKAMI Tomoko
    Department of Anesthesiology, National Hospital Organization Kokura Medical Center
  • KAWASAKI Rika
    Department of Anesthesiology, National Hospital Organization Kokura Medical Center
  • FUKUCHI Kaho
    Department of Anesthesiology, National Hospital Organization Kokura Medical Center
  • CHO Sungsam
    Department of Anesthesiology, National Hospital Organization Kokura Medical Center
  • SHIROZU Kazuhiro
    Department of Anesthesiology and Critical Care Medicine, Kyushu University Hospital
  • YAMAURA Ken
    Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University

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  • 人工膝関節置換手術後の悪心・嘔吐と食事摂取量に対するオンダンセトロンの効果の検討

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<p>Patients who underwent knee arthroplasty under general anesthesia were evaluated for the incidence of postoperative nausea and vomiting（PONV）and food intake in a retrospective observational study. They were divided into two groups：30 patients who received ondansetron at the end of surgery（ONDA group）and 29 patients who did not receive ondansetron（CONT group）. The incidence of PONV, antiemetic drug use, and iv-PCA discontinuation rate were all significantly lower in the ONDA group. Mean food intake up to the first postoperative day was significantly higher in the ONDA group and significantly lower in the group with PONV than in the group without PONV. These results suggest that Ondansetron can be effective in the treatment of PONV and food intake after knee arthroplasty.</p>

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