Pharmaceutical Inspection by High-Frequency Accurate CW GaP Terahertz Spectrometer

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  • SASAKI Tetsuo
    Graduate School of Medical Photonics, Shizuoka University Research Institute of Electronics, Shizuoka University
  • SAKAMOTO Tomoaki
    Research Institute of Electronics, Shizuoka University
  • OTSUKA Makoto
    Research Institute of Electronics, Shizuoka University

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  • 高い周波数精度を持つ連続波GaP テラヘルツ分光　スペクトル測定装置を利用した医薬品検査
  • タカイ シュウハスウ セイド オ モツ レンゾクハ GaP テラヘルツ ブンコウ スペクトル ソクテイ ソウチ オ リヨウ シタ イヤクヒン ケンサ

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Since terahertz (THz) spectra are sensitive to crystal structures, they are available for crystal polymorph identification and quantification. They can also be utilized to detect defects in crystal, such as impurity molecules. Thus, THz spectroscopy provide high sensitivity and a low detection limit for pharmaceutical inspection. In this paper, we first present our originally developed high-frequency accurate CW Gallium Phosphide (GaP) THz spectrometer and then demonstrate trace impurity detection in pharmaceuticals. Such high-frequency accurate spectroscopy has potential for the inspection of middle molecular weight (MMW) pharmaceuticals, which are expected to become mainstream in the near future.

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