A fatal case of pyogenic spondylitis rapidly progressing to epidural abscess caused by a novel ST-type methicillin-susceptible <i>Staphylococcus aureus</i> ST9378

DOI
  • Inoue Takeru
    Department of infectious disease, Karatsu Red Cross Hospital, Saga, Japan.
  • Setoguchi Tomoe
    Department of infectious disease, Karatsu Red Cross Hospital, Saga, Japan.
  • Akashi Michiaki
    Department of pathology, Karatsu Red Cross Hospital, Saga, Japan.
  • Shimono Nobuyuki
    Center for the Study of Global Infection, Kyushu University Hospital, Fukuoka, Japan.
  • Iwao Yasuhisa
    Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Kutsuno Shoko
    Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Hisatsune Junzo
    Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan.

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Description

<p>Pyogenic spondylitis can be life-threatening; however, its diagnosis remains challenging because of the initial presentation of nonspecific symptoms. Given the vulnerability of the infected site, patients are highly at risk for severe complications, such as epidural abscesses or bacterial meningitis, which can considerably worsen the prognosis. Herein, we report a case of lumbar pyogenic spondylitis initially identified through methicillin-susceptible Staphylococcus aureus bacteremia, which subsequently progressed to an epidural abscess. The abscess rapidly ascended to the cervical region, causing bacterial meningitis and ultimately, a fatal outcome. The strain (JARB-OU3818) was positive for the virulence factor genes of the enterotoxin gene cluster (seg, sei, sem, sen, and seo) but negative for the Panton-Valentine leucocidin (PVL) and toxic shock syndrome toxin-1 (TSST-1) coding genes. Additionally, JARB-OU3818 was ST9378 belonging to the clonal complex 45 lineage. Clinicians should recognize that pyogenic spondylitis may follow an aggressively progressive clinical course, as demonstrated by this case.</p>

Journal

  • GHM Open

    GHM Open advpub (0), 2025

    National Center for Global Health and Medicine

Keywords

Details 詳細情報について

  • CRID
    1390304338692762624
  • DOI
    10.35772/ghmo.2025.01001
  • ISSN
    24362956
    2436293X
  • Text Lang
    en
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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