The Uric Acid to High-Density Lipoprotein Cholesterol Ratio Is Associated with Left Ventricular Diastolic Function in Patients with No Significant Perfusion Abnormality
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- Yamamoto Ryotaro
- Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital
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- Fukuda Yukihiro
- Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital
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- Kawaguchi Takafumi
- Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital
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- Kimura Keita
- Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital
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- Morita Masashi
- Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital
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- Hironobe Naoya
- Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital
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- Itakura Kiho
- Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital
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- Tomomori Shunsuke
- Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital
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- Urabe Yoji
- Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital
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- Oka Toshiharu
- Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital
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- Mitsuba Naoya
- Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital
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- Ueda Hironori
- Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital
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- Nakano Yukiko
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
書誌事項
- タイトル別名
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- Assessment by Myocardial Perfusion Single-Photon Emission Computed Tomography
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説明
<p>The ratio of uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) is a marker of inflammation. However, whether this ratio is associated with left ventricular (LV) diastolic function remains unknown. This study tested the hypothesis that the UA-to-HDL-C ratio is associated with LV diastolic parameters derived from gated myocardial perfusion single-photon emission computed tomography (SPECT) in patients with no significant perfusion abnormalities.</p><p>The study population included 204 patients with no significant perfusion abnormalities and a preserved ejection fraction. The peak filling rate (PFR) and one-third mean filling rate (1/3 MFR) were obtained as LV diastolic parameters using gated SPECT. Serum UA and plasma HDL-C levels were also examined.</p><p>Significant associations were observed between the UA-to-HDL-C ratio and the PFR (r = −0.20; P = 0.005) and 1/3 MFR (r = −0.17; P = 0.018). Multivariate linear regression analysis was performed to determine the factors associated with LV diastolic parameters. Age (β = −0.13; P = 0.046), the LV end-diastolic volume (β = −0.17; P = 0.046), and the UA-to-HDL-C ratio (β = −0.17; P = 0.023) were significantly associated with the PFR. Moreover, age (β = −0.18; P = 0.011), the LV mass index (β = −0.19; P = 0.011), and the UA-to-HDL-C ratio (β = −0.14; P = 0.047) were significantly associated with the 1/3 MFR.</p><p>These results demonstrated that the UA-to-HDL-C ratio is associated with LV diastolic function derived from gated SPECT in patients with no significant perfusion abnormalities.</p>
収録刊行物
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- International Heart Journal
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International Heart Journal 66 (3), 413-419, 2025-05-31
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
