Clinical practice of a novel molecular diagnostic method for detecting <i>Helicobacter pylori</i> and clarithromycin resistance

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  • Kameoka Eisuke
    Department of Gastroenterology, Japanese Red Cross Society Fukushima Hospital Department of Gastroenterology, Fukushima Medical University School of Medicine
  • Hikichi Takuto
    Department of Endoscopy, Fukushima Medical University Hospital
  • Konno Naoki
    Department of Gastroenterology, Japanese Red Cross Society Fukushima Hospital
  • Irie Hiroki
    Department of Gastroenterology, Japanese Red Cross Society Fukushima Hospital
  • Kanno Yukiko
    Department of Gastroenterology, Japanese Red Cross Society Fukushima Hospital
  • Ishizaki Yuto
    Department of Gastroenterology, Japanese Red Cross Society Fukushima Hospital Department of Gastroenterology, Fukushima Medical University School of Medicine
  • Goto Sayuri
    Department of Gastroenterology, Japanese Red Cross Society Fukushima Hospital
  • Kuroda Masahito
    Department of Gastroenterology, Japanese Red Cross Society Fukushima Hospital
  • Otsuka Mitsuru
    Department of Gastroenterology, Fukushima Medical University School of Medicine
  • Yanagita Takumi
    Department of Gastroenterology, Fukushima Medical University School of Medicine Department of Endoscopy, Fukushima Medical University Hospital
  • Kato Tsunetaka
    Department of Gastroenterology, Fukushima Medical University School of Medicine Department of Endoscopy, Fukushima Medical University Hospital
  • Nakamura Jun
    Department of Gastroenterology, Fukushima Medical University School of Medicine Department of Endoscopy, Fukushima Medical University Hospital
  • Ohira Hiromasa
    Department of Gastroenterology, Fukushima Medical University School of Medicine
  • Kodama Kenta
    Department of Gastroenterology, Japanese Red Cross Society Fukushima Hospital

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Description

<p>Abstract</p><p>Objective: The Smart GeneTM system enables the rapid polymerase chain reaction-based detection of Helicobacter pylori (H. pylori) in gastric juice and determines clarithromycin (CAM) resistance. This study evaluated the clinical utility of the Smart GeneTM system for diagnosing and managing H. pylori infection.</p><p>Methods:H. pylori diagnosis was obtained using the Smart GeneTM system and the effectiveness of individualized eradication therapy was evaluated. Treatment regimens were chosen based on CAM sensitivity in the Smart GeneTM test.</p><p>Results: A total of forty-nine patients were assessed. Among them, 28 had H. pylori infection, while 3 had CAM resistance. Seventeen patients underwent H. pylori eradication therapy. Fourteen patients with CAM-sensitive strains underwent eradication therapy with vonoprazan (VPZ), amoxicillin (AMPC), and CAM. Two patients with CAM-resistant strains were treated with VPZ and AMPC, while one received VPZ, AMPC, and metronidazole. The eradication achievement rate was 100%. Of 31 outpatients, 61.5% began H. pylori eradication therapy on the same day as the Smart GeneTM test.</p><p>Conclusion: Smart GeneTM enables rapid diagnosis of H. pylori infection and the detection of CAM resistance, allowing for personalized eradication regimens.</p>

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Details 詳細情報について

  • CRID
    1390304582042723072
  • DOI
    10.5387/fms.25-00004
  • ISSN
    21854610
    00162590
  • PubMed
    40545358
  • Text Lang
    en
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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