A patient with argininosuccinate synthase 1 positive unclassified hepatocellular adenoma causing intratumoral hemorrhage
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- Takashima Hidetaka
- Departments of Gastroenterology and Hepatology, Osaka General Hospital of WEST Japan Railway Company
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- Mizuno Shigeto
- Departments of Endoscopy, Kindai University Nara Hospital
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- Mori Takahiro
- Departments of Gastroenterology and Hepatology, Osaka General Hospital of WEST Japan Railway Company
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- Yokomizo Chihiro
- Departments of Gastroenterology and Hepatology, Osaka General Hospital of WEST Japan Railway Company
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- Ikeda Kyohei
- Departments of Gastroenterology and Hepatology, Osaka General Hospital of WEST Japan Railway Company
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- Ogiso Kiyoshi
- Departments of Gastroenterology and Hepatology, Osaka General Hospital of WEST Japan Railway Company
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- Uejima Hirokazu
- Departments of Gastroenterology and Hepatology, Osaka General Hospital of WEST Japan Railway Company
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- Ito Tadashi
- Departments of Gastroenterology and Hepatology, Osaka General Hospital of WEST Japan Railway Company
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- Tomioka Hideo
- Departments of Gastroenterology and Hepatology, Osaka General Hospital of WEST Japan Railway Company
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- Okamoto Toshiyuki
- Departments of Radiology, Osaka General Hospital of WEST Japan Railway Company
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- Nakaseko Yuri
- Departments of Radiology, Osaka General Hospital of WEST Japan Railway Company
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- Hayashi Natsuko
- Departments of Radiology, Osaka General Hospital of WEST Japan Railway Company
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- Katoh Takeharu
- Departments of Radiology, Osaka General Hospital of WEST Japan Railway Company
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- Masaki Takeshi
- Departments of Pathology, Osaka General Hospital of WEST Japan Railway Company
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- Shimizu Seiji
- Departments of Gastroenterology and Hepatology, Osaka General Hospital of WEST Japan Railway Company
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- Moriguchi Michihisa
- Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science
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- Nakanuma Yasuni
- Department of Diagnostic Pathology, Shizuoka Cancer Center
Bibliographic Information
- Other Title
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- 腫瘍内出血を生じたargininosuccinate synthase 1陽性，分類不能型肝細胞腺腫の一例
- 症例報告 腫瘍内出血を生じたargininosuccinate synthase 1陽性,分類不能型肝細胞腺腫の一例
- ショウレイ ホウコク シュヨウ ナイシュッケツ オ ショウジタ argininosuccinate synthase 1 ヨウセイ,ブンルイ フノウガタ カン サイボウセン シュ ノ イチレイ
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Abstract
<p>We report the first Japanese patient with unclassified hepatocellular adenoma who presented with acute pain in the abdomen due to intratumoral hemorrhage and whose immunohistological study revealed high tumoral expression of argininosuccinate synthase 1 (ASS1). A 47-year-old woman was referred to our hospital with severe abdominal pain and liver tumors. An abdominal contrast-enhanced computed tomograhy demonstrated multiple hypervascular liver tumors, some of which had hemorrhage and necrosis. Upon tumor biopsy, we found smaller hepatocytes with larger nuclei and the immunohistological study led to the diagnosis of unclassified hepatocellular adenoma. Additional examinations confirmed a high expression of ASS1, a marker for unclassified hepatocellular adenoma. ASS1 expression has been associated with intratumoral bleeding, which is consistent with the clinical course of our patient.</p>
Journal
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- Kanzo
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Kanzo 60 (9), 338-346, 2019-09-01
The Japan Society of Hepatology
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Keywords
Details 詳細情報について
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- CRID
- 1390564227299065216
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- NII Article ID
- 130007701682
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- NII Book ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- NDL BIB ID
- 029930824
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
