Cancer surveillance in patients with Li-Fraumeni syndrome

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  • リー・フラウメニ症候群に対するがんサーベイランス

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<p>With the spread of cancer genomic medicine, an increase in the number of patients found to have cancer predispositions is expected. However, medical systems such as cancer surveillance programs for patients with cancer predispositions, especially Li-Fraumeni syndrome (LFS), which is predicted to be diagnosed most frequently in pediatric cancer patients, have not yet been established. I will discuss the feasibility of LFS cancer surveillance in Japan by reviewing six published articles about ongoing surveillance programs and an article on the meta-analysis of whole-body MRI (WBMRI), which is frequently used in cancer surveillance. Overseas, the progress reports of the ‘Toronto protocol’ conducted under the Toronto/Utah/CHLA LFS study are positively accepted, and on the basis of this protocol, 12 cancer surveillance programs are in progress in six countries. The number of patients with positive results as determined by WBMRI is high and the cancer detection rate is sufficiently high at 7%. Early detection and treatment of cancer may improve the overall survival of LFS patients. It is desirable to advance cancer surveillance research for LFS patients in Japan.</p>

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