Development of SiN nanopore sensors for direct DNA sequencing

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  • YANAGI Itaru
    Hitachi Ltd, Research and Development Group, Biosystems Research Dept
  • AKAHORI Rena
    Hitachi Ltd, Research and Development Group, Biosystems Research Dept
  • GOTO Yusuke
    Hitachi Ltd, Research and Development Group, Biosystems Research Dept
  • TAKEDA Kenichi
    Hitachi Ltd, Research and Development Group, Biosystems Research Dept

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Other Title
  • SiNナノポアを用いたDNA直接解読技術の開発
  • SiN ナノポア オ モチイタ DNA チョクセツ カイドク ギジュツ ノ カイハツ

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Abstract

<p>This paper summarizes the latest developments regarding solid-state nanopores achieved in our laboratory. To realize DNA sequencing with solid-state nanopores, many issues must be resolved. In particular, from the standpoint of device fabrication and DNA manipulation, we believe that there are three key issues: (1) stable fabrication of a small nanopore with a diameter on the same order as that of DNA, (2) fabricating an ultrathin membrane, and (3) decreasing the DNA translocation speed through a nanopore. We addressed these three issues, and successfully observed sequence-specific currents through a nanopore while DNA remained in the nanopore.</p>

Journal

  • Oyo Buturi

    Oyo Buturi 88 (4), 262-266, 2019-04-10

    The Japan Society of Applied Physics

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